Case # | Age/Gender | Involved sites at presentation | Immunophenotype | Karyotype 1 | FISH 2(% cells) | Therapy 3 | Outcome/Follow up | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nodal | Extranodal | BCL2 | BCL6 | CD10 | CD38 | MUM1 | sIg | Ki-67% | ||||||
1 | 52/M | Paraaortic, pancreatic, portohepatic, cervical, axillary, mediastinal | NA | + | + | - | NA | NA | λ | 100 | Complex4 | IGH x 3 (100%) | IC | DIED/8 Months |
2 | 24/M | Left external iliac | Left femoral neck | + | + | + | NA | + | - | 75-80 | 46,XY | IGH/C-MYC (46%), IGH x 3–4 (51%) | IC, HSCT | DIED/20 Months |
3 | 61/F | NA | Left maxillary sinus | + | + | - | NA | + | κ | 100 | 46,XX | IGH x 3 (20%) | IC, HSCT | ALIVE/105 Months (Multiple Relapses) |
4 | 68/F | Gastrohepatic, periaortic, pericaval, mesenteric | NA | + | + | + | + | NA | κ | 95-99 | NA | IGH/BCL2 (91.5%), C-MYC x 3–4 (87%), IGH x 3 (42%) | IC | ALIVE/42 Months |
5 | 44/M | NA | Right submandibular space, right lateral neck | + | + | + | + | NA | κ | 100 | NA | IGH/C-MYC, C-MYC x 3–4, IGH x 3–6, BCL2 x 3–6 (96%) | IC, EBRT | DIED/6 Months |
6 | 4/M | Retroperitoneal, mesenteric | Liver, Omentum | + | + | + | + | NA | κ | 95-99 | NA | C-MYC x 3 (13%), IGH x 3 (17%) | IC, HSCT | DIED/6 Months |