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Figure 2 | Biomarker Research

Figure 2

From: IGH amplification in patients with B cell lymphoma unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt’s lymphoma

Figure 2

Cytogenetic findings. (A) Interphase nuclear FISH from Case 5 using the LSI IGH(14q32) Dual Color Break Apart Rearrangement (BAR) probe (Abbott Molecular Des Plaines, Il) demonstrates amplification of IGH (four fusion signals). (B) Interphase nuclear FISH from Case 5 using the LSI IGH(14q32)/MYC(8q24)/Cep8(p11-q11) Tri Color Dual Fusion (DF) probe (Abbott Molecular Des Plaines, Il) demonstrates amplification of IGH (green), a t(8:14)(q24;q32) (red and yellow) and a normal signal pattern for the 8p11-q11 region of chromosome 8 (aqua). (C) Interphase nuclear FISH from Case 4 using the same DF probe demonstrates amplification of both IGH (green) and MYC (red) and a normal signal pattern for the 8p11-q11 region of chromosome 8 (aqua).

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Biomarker Research

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