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Table 5 FISH probes that are commonly used for clinical diagnosis of hematological diseases

From: Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine

Probes Cytogenetic anomaly Associated disorders
BCR/ABL t(9;22)(q34;q11) CML, ALL, AML-M1, AML-M2, MPD
PML/RARĪ± t(15;17)(q22;q21) AML-M3, CML Ph+
AML1/ETO t(8;21)(q22;q22) AML-M2, AML-M4, MDS
MLL (11q23) t(1;11)(p32;q23) ALL, AML
t(1;11)(q21;q23) AML-M4, AML-M5
t(2;11)(p21;q23) MDS
t(4;11)(q21;q23) ALL, AML
t(6;11)(q27;q23) AML-M4, AMl-M5
t(9;11)(p22;q23) ALL, AML-M5, MDS, t-MDS
t(10;11)(p13;q23) AML-M4, AMl-M5
t(11;17)(q23;q21) AML-M3, AML-M4, AMl-M5
t(11;19)(q23;p13) ALL, AML-M4, AML-M5, t-AMl
t(X;11)(q13;q23) T-ALL
del(11q23) AML, ALL, CLD, CLL, MDS, NHL
CBFB (16q22) t(16;16)(p13;q22) AML-M4Eo, MDS
inv(16)(p13q22) AML-M4Eo
del(16q22) AML, AML-M4Eo, NHL
EVI1 (3q26) t(3;3)(q21;q26) AML, MDS
inv(3)(q21q26) AML-M4, AML-M6, CML Ph+, MDS
t(3;21)(q26;q22) AML, CML Ph+, MDS
FGFR1/D8Z2 (8p11) t(8;13)(p11;q12) MPD
t(8;16)(p11;p13) AML-M4, AML-M5
TEL/AML1 t(12;21)(p13;q22) ALL
TCF3/PBX1 t(1;19)(q23;p13) pre-B ALL
CKS1B (1q21)/CDKN2C (1p32) dup(1)(q21q32) ALL, CLD, NHL
del(1)(q21) NHL
del(1)(p32p36) CLD, NHL
MYC (8q24) t(2;8)(p12;q24) ALL-L3, BL, NHL
t(8;14)(q24;q32) ALL-L3, BL, MM, NHL
t(8;14)(q24;q11) T-ALL
t(8;22)(q24;q11) ALL-L3, BL
CEP8 +8 ALL, AML, CLD, MPD, MDS, PV
EGR1 (5q31)/D5S721 (5p15.2) -5 AML, MDS
del(5)(q13q33) AML, MDS, MPD, 5q- syn
D7S486 (7q31)/CEP7 (7p11.1-7q11.1) -7 AML, MDS, MPD
del(7)(q11) ALL, AML, MDS
del(7)(q22q34) AML, CLD, CMD, MDS, NHL
D20S108 (20q12) del(20)(q11q13) AML, CMD, MDS, PV
-20 ALL
RB-1 (13q14) del(13)(q12-q22) AML, AMM, CLD, CLL, MM, MDS, NHL
del(13)(q12-q14) AML, AMM, CLD, MDS, NHL
P53 (17p13.1) del(17)(p13.1) ALL, AML, CLD, MDS, NHL
-17 CLL
IGH (14q32) del(14q32) CLD, NHL
t(2;14)(p13;q32) B-CLL
t(3;14)(q27;q32) DLCL, FL
t(4;14)(p13;q32) MM
t(5;14)(q31;q32) ALL
t(6;14)(p25;q32) MM
t(8;14)(q24;q32) ALL
t(9;14)(p12-13;q32) B-NHL, LPL
t(11;14)(q13;q32) B-PLL, CLD, MM, MCL, MGUS, NHL
t(14;16)(q32;q23) MM
t(14;18)(q32;q21) CLD, FL, DLCL, MM, NHL
t(14;19)(q32;q13) CLD, CLL, NHL
t(14;22)(q32;q11) ALL
ATM (11q22.3) del(11)(q13q14-q23) AML, CLD, CLL, MDS, NHL
FGFR3/IGH t(4;14)(p13;q32) MM
MAF/IGH t(14;16)(q32;q23) MM
CCND1/IGH t(11;14)(q13;q32) B-PLL, CLD, MM, MCL, MGUS, NHL
CEP12 +12 AML, CLL, CLD, NHL
BCL6 (3q27) t(3;14)(q27;q32) DLCL, FL
t(3;22)(q27;q11) DLCL, FL
BCL2 (18q21) t(11;18)(q21;q21) MZL, NHL
t(14;18)(q32;q21) CLD, FL, DLCL, MM, NHL
del(18)(q21) AML, CLD, NHL
-18 CLD
+18 ALL, CLD
CEPX/Y XY/XX ALLO-SCT
-Y ALL, AML, CLD, MDS, MM, MPD, NHL, PV