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Table 5 FISH probes that are commonly used for clinical diagnosis of hematological diseases

From: Fluorescence in situ hybridization (FISH): an increasingly demanded tool for biomarker research and personalized medicine

Probes

Cytogenetic anomaly

Associated disorders

BCR/ABL

t(9;22)(q34;q11)

CML, ALL, AML-M1, AML-M2, MPD

PML/RARα

t(15;17)(q22;q21)

AML-M3, CML Ph+

AML1/ETO

t(8;21)(q22;q22)

AML-M2, AML-M4, MDS

MLL (11q23)

t(1;11)(p32;q23)

ALL, AML

t(1;11)(q21;q23)

AML-M4, AML-M5

t(2;11)(p21;q23)

MDS

t(4;11)(q21;q23)

ALL, AML

t(6;11)(q27;q23)

AML-M4, AMl-M5

t(9;11)(p22;q23)

ALL, AML-M5, MDS, t-MDS

t(10;11)(p13;q23)

AML-M4, AMl-M5

t(11;17)(q23;q21)

AML-M3, AML-M4, AMl-M5

t(11;19)(q23;p13)

ALL, AML-M4, AML-M5, t-AMl

t(X;11)(q13;q23)

T-ALL

del(11q23)

AML, ALL, CLD, CLL, MDS, NHL

CBFB (16q22)

t(16;16)(p13;q22)

AML-M4Eo, MDS

inv(16)(p13q22)

AML-M4Eo

del(16q22)

AML, AML-M4Eo, NHL

EVI1 (3q26)

t(3;3)(q21;q26)

AML, MDS

inv(3)(q21q26)

AML-M4, AML-M6, CML Ph+, MDS

t(3;21)(q26;q22)

AML, CML Ph+, MDS

FGFR1/D8Z2 (8p11)

t(8;13)(p11;q12)

MPD

t(8;16)(p11;p13)

AML-M4, AML-M5

TEL/AML1

t(12;21)(p13;q22)

ALL

TCF3/PBX1

t(1;19)(q23;p13)

pre-B ALL

CKS1B (1q21)/CDKN2C (1p32)

dup(1)(q21q32)

ALL, CLD, NHL

del(1)(q21)

NHL

del(1)(p32p36)

CLD, NHL

MYC (8q24)

t(2;8)(p12;q24)

ALL-L3, BL, NHL

t(8;14)(q24;q32)

ALL-L3, BL, MM, NHL

t(8;14)(q24;q11)

T-ALL

t(8;22)(q24;q11)

ALL-L3, BL

CEP8

+8

ALL, AML, CLD, MPD, MDS, PV

EGR1 (5q31)/D5S721 (5p15.2)

-5

AML, MDS

del(5)(q13q33)

AML, MDS, MPD, 5q- syn

D7S486 (7q31)/CEP7 (7p11.1-7q11.1)

-7

AML, MDS, MPD

del(7)(q11)

ALL, AML, MDS

del(7)(q22q34)

AML, CLD, CMD, MDS, NHL

D20S108 (20q12)

del(20)(q11q13)

AML, CMD, MDS, PV

-20

ALL

RB-1 (13q14)

del(13)(q12-q22)

AML, AMM, CLD, CLL, MM, MDS, NHL

del(13)(q12-q14)

AML, AMM, CLD, MDS, NHL

P53 (17p13.1)

del(17)(p13.1)

ALL, AML, CLD, MDS, NHL

-17

CLL

IGH (14q32)

del(14q32)

CLD, NHL

t(2;14)(p13;q32)

B-CLL

t(3;14)(q27;q32)

DLCL, FL

t(4;14)(p13;q32)

MM

t(5;14)(q31;q32)

ALL

t(6;14)(p25;q32)

MM

t(8;14)(q24;q32)

ALL

t(9;14)(p12-13;q32)

B-NHL, LPL

t(11;14)(q13;q32)

B-PLL, CLD, MM, MCL, MGUS, NHL

t(14;16)(q32;q23)

MM

t(14;18)(q32;q21)

CLD, FL, DLCL, MM, NHL

t(14;19)(q32;q13)

CLD, CLL, NHL

t(14;22)(q32;q11)

ALL

ATM (11q22.3)

del(11)(q13q14-q23)

AML, CLD, CLL, MDS, NHL

FGFR3/IGH

t(4;14)(p13;q32)

MM

MAF/IGH

t(14;16)(q32;q23)

MM

CCND1/IGH

t(11;14)(q13;q32)

B-PLL, CLD, MM, MCL, MGUS, NHL

CEP12

+12

AML, CLL, CLD, NHL

BCL6 (3q27)

t(3;14)(q27;q32)

DLCL, FL

t(3;22)(q27;q11)

DLCL, FL

BCL2 (18q21)

t(11;18)(q21;q21)

MZL, NHL

t(14;18)(q32;q21)

CLD, FL, DLCL, MM, NHL

del(18)(q21)

AML, CLD, NHL

-18

CLD

+18

ALL, CLD

CEPX/Y

XY/XX

ALLO-SCT

-Y

ALL, AML, CLD, MDS, MM, MPD, NHL, PV