Figure 3
From: Vav2 protein overexpression marks and may predict the aggressive subtype of ductal carcinoma in situ
Differential expression of IGF-IR, Rap1, and Vav2 in DCIS, DCIS with microinvasion, DCIS/LCIS with invasion >1 mm. (A) Representative monochrome images of Vav2 staining in normal mammary epithelium, DCIS, DCIS/T1mic, DCIS/IDC, and IDC. Original magnification (x200). Insets, enlarged images of epithelial cells. Arrows, suspected microinvasion. (B) Box plots for unaggregated measurements of IGF-IR, Rap1, and Vav2 in the groups of tissue: normal mammary epithelium, DCIS, DCIS/T1mic, and DCIS/IDC + LCIS/ILC. +, mean value. Horizontal lines, medians. Boxes, 25th and 75th percentile. Whiskers, 75th +1.5 x IQR and 25th -1.5 x IQR. Dots, group outliers. Y axis, protein levels in relative units. (C) The ROC curves for averaged measurements of IGF-IR, Rap1, and Vav2 protein expression.