Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia

Table 2 Patient characteristics and distributions of IDH mutations for all patients and within groups

CHARACTERISTIC	All	*IDH1* codon 132:		*IDH1* codon 105 (synonymous SNP):		*IDH2* codon 140:		*IDH2* codon 172:
Total n = 189		*Wild type*	*Mutation*	*Wild type*	*Variant*	*Wild type*	*Mutation*	*Wild type*	*Mutation*
Age median (range), years	64 (19–88)	63 (19–85)	70 (30–88)*	64 (19–88)	66 (29–84)	63 (19–88)	66 (37–83)*	64 (19–88)	72 (46–74)*
Gender
Male	95	90	5	85	10	85	10	92	3
Female	94	84	10	84	10	83	11	92	2
Karyotype
Normal	108	99	9	95	13	96	12	106	2
Aberrant	75	69	6	68	7	66	9	72	3
Missing data	6	6		6		6		6
Risk group
Low	32	31	1	30	2	29	3	31	1
Intermediate	87	80	7	72	15	75	12	86	1
High	55	51	4	52	3	51	4	52	3
Missing data	15	12	3	15		13	2	14	1
FLT3 status
FLT3 wild type	116	109	7	104	12	101	15	114	2
FLT3-ITD	37	34	3	32	5	33	4	36	1
Missing data**	36	31	5	33	3	34	2	34	2
NPM1 status
NPM1 wild type	99	92	7	87	12	88	11	96	3
NPM1 mutation	52	49	3	47	5	44	8	52	0
Missing data**	38	33	5	35	3	36	2	36	2
Induction treatment response
Complete remission	132	122	10	119	13	119	13	127	5
Not complete remission	49	44	5	43	6	43	6	49	0
Missing information	8	8	0	7	1	6	2	8	0
IDH1 codon 132
Wild type	174			157	17	153	21	169	5
Mutation	15			12	3	15	0	15	0
IDH1 codon 105 (synonymous SNP)
Wild type	169					151	18	165	5
Variant	20					17	3	19	1
IDH2 codon 140
Wild type	168							163	5
Mutation	21							21	0
IDH2 codon 172
Wild type	184
Mutation	5

*Mann–Whitney test for difference in age distribution between patients with IDH mutation (IDH1 or IDH2) and IDH wildtype patients, median 62 vs 69 years; p = 0.036.
**FLT3-ITD and NPM1 mutations were not routinely analyzed in all non-normal karyotype patients.

ISSN: 2050-7771