Skip to main content

Advertisement

Table 2 Distribution of genotype and allele frequencies in patients and in controls; in subgroup and in response to anti-VEGF

From: Vascular endothelial growth factor genetic polymorphisms and susceptibility to age-related macular degeneration in Tunisian population

SNPs   Patients n = 145 Controls n = 207 G1 n = 117 G2 n = 28 GR n = 52 PR n = 16
   n (%) n (%) n (%) n (%) n (%) n (%)
(−2578) CC 19 (13.10) 38 (18.35) 16 (13.67) 3 (10.71) 4 (7.7) 4 (25)
  CA 67 (46.21) 88 (42.51) 57 (48.71) 10 (35.71) 24 (46.1) 9 (56.2)
  AA 59 (40.69) 81 (39.13) 44 (37.60) 15 (53.57) 24 (46.1)*** 3 (18.8)
  C 0.362 0.397 0.380 0.286 0.308 0.531
  A 0.638 0.603 0.620 0.714 0.692 0.468
(+405) GG 55 (37.93)* 97 (46,7) 46 (39.31) 9 (32.14) 15 (28.9) 7 (43.8)
  GC 51 (35.17) 92 (44.4) 42 (35.89) 9 (32.14) 21 (40.4) 6 (37.5)
  CC 39 (26.90) 18 (8.9) 29 (24.78) 10 (35.71) 16 (30.7) 3 (18.8)
  G 0.555* 0.688 0.573 0.482 0.490 0.625
  C 0.445 0.311 0.427 0.518 0.510 0.375
(+936) CC 101 (69.65) 168 (81.1) 83 (70.94) 18 (64.28) 41 (78.8) 12 (75)
  CT 38 (26.21) 38 (18.3) 30 (25.64) 8 (28.57) 11 (21.1) 2 (12.5)
  TT 6 (4.14)** 1 (0.6) 6 (3.41) 2 (7.14) 0 2 (12.5)****
  C 0.828 0.903 0.838 0.786 0.894 0.810
  T 0.172** 0.097 0.179 0.214 0.106 0.190
  1. *Homozygous GG genotype and G allele were significantly higher in AMD patients than in controls [(OR: 3.86, 95%CI [2.03 - 7.42], p = 5 × 10−6 and OR: 1.79, 95%CI [1.3 - 2.48], p = 2 × 10−4 respectively)].
  2. **Homozygous TT genotype and T allele were significantly higher in AMD patients than in controls [(OR: 8.89, 95%CI [1. 05–198.1], p = 0.021 and OR: 1.95, 95%CI [1. 22–3.12], p = 0.003 respectively)].
  3. ***Homozygous AA (−2578) genotype was statistically associated with good response [(OR: 0.27, 95%CI [0.07- 1.06], p = 0.042)].
  4. ****Homozygous TT (+936) genotype was statistically associated with poor response [(OR: 1.61, 95%CI [0.31-8.28], p = 0.014].