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Table 1 Atypical Hodgkin’s Lymphoma with liver involvement

From: CEPP regimen (cyclophosphamide, etoposide, procarbazine and prednisone) as initial treatment for Hodgkin lymphoma patients presenting with severe abnormal liver function

Author

No. of cases

Clinical presentation

Hepatic functions

Regimen

Reference

Thakar, et al., 2014

2

Case1: Fever, jaundice, altered mental status, renal failure, pancytopenia

Case1:

CEPP: Cyclophosphamide, Etoposide, Procarbazine, Prednisone

This paper

Case 2: Fever, chills, night sweats fatigue, itchiness, weight loss

T Bil: 13 mg/dL

D Bil: 10.3 mg/dL

AST: 392 IU/dL ALT: 312 IU/dL

T Bil: 2.5 mg/dL

AST: 359 IU/dL ALT: 437 IU/dL

Guha, et al., 2010

1

Fever, jaundice, weight loss, acute hepatic failure, enlarged lymph nodes

T Bil: 9 mg/dL

Only intravenous antibiotics and supportive care

[19]

D Bil: 6 mg/dL

AST: 50 U/L

ALT: 80 U/L

Orellana, et al., 2012

1

Jaundice, choluria, malaise, enlarged groin lymph nodes, and weight loss

T Bil: 18 mg/dL

Dexamethasone, Gemcitabine & Cisplatin (GDP) × 4 cycles followed by Adriamycin, Bleomycin, Vinblastine & Dacarbazine

[20]

AST: 286 U/L

ALT: 177 U/L

Rosque, et al., 2011

1

Abdominal pain, fever, jaundice, intermittent bloody diarrhea, weight loss, hepatosplenomegaly, bowel obstruction

T Bil: 10 mg/dL

High dose intravenous steroids, modified MOPP (mechlorethamine and prednisone without Vincristine & Procarbazine) × 3 cycles

[18]

D bil: 7.8 mg/dL AST: 137 U/L

   

ALT: 199 U/L

  
  1. T Bil total bilirubin, D Bil direct bilirubin, AST aspartate aminotransferase, ALT alanine aminotransferase.