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Table 2 Hazard ratios of death and recurrence according to clinicopathological factors and RBM3 expression in cases with radically resected primary tumours and radically resected primary tumours/distant metastasis-free disease, respectively

From: High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death

   Overall survival - R0 resection Recurrence free survival - R0 resection + M0 disease
   Unadjusted p-value Adjusted p-value   Unadjusted p-value Adjusted p-value
  n (events) HR (95% CI)   HR (95% CI)   n (events) HR (95% CI)   HR (95% CI)  
Age           
Continuous 120 (65) 1.04 (1.02-1.07) <0.001 1.06 (1.03-1.09) <0.001 86 (65) 1.00 (0.97-1.03) 0.909 1.03 (0.99-1.07) 0.100
Gender           
Female 26 (15) 1.00 0.843 1.00 0.915 16 (3) 1.00   1.00  
Male 94 (50) 0.85 (0.48.1.52)   0.97 (0.51-1.83)   70 (32) 2.83 (0.87.9.26) 0.084 3.31 (0.96-11.40)) 0.058
T-stage           
T1 17 (5) 1.00   1.00   10 (1) 1.00   1.00  
T2 31 (17) 2.12 (0.81-6.00) 0.119 1.35 (0.46-3.99) 0.582 24 (7) 3.26 (0.40-6.00) 0.269 3.12 (0.30-31.88) 0.338
T3 56 (34) 2.59 (1.01-6.64) 0.047 1.04 (0.36-3.00) 0.942 43 (22) 6.42 (0.86-47.71) 0.069 3.90 (0.41-36.99) 0.236
T4 15 (9) 3.04 (1.01-9.08) 0.047 1.24 (0.35-4.35) 0.739 8 (5) 10.06 (1.17-86.42) 0.035 4.38 (0.35-55.05) 0.253
N-stage           
N0 45 (18) 1.00   1.00   35 (3) 1.00   1.00  
N1 23 (11) 1.30 (0.61-2.76) 0.489 1.67 (0.79-3.58) 0.188 18 (10) 8.08 (2.22-29.40) 0.001 12.36 (3.19-47.86) <0.001
N2 27 (17) 1.98 (1.02-3.84) 0.045 2.65 (1.32-5.31) 0.006 22 (13) 10.53 (2.99-37.06) <0.001 13.07 (3.52-48.53) <0.001
N3 25 (19) 3.36 (1.75-6.47) <0.001 4.85 (2.42-9.70) <0.001 11 (9) 18.01 (4.81-67.44) <0.001 27.19 (6.64-111.25) <0.001
M-stage           
M0 96 (50) 1.00   1.00   96 (50) 1.00   1.00  
M1 10 (9) 2.74 (1.34-5.59) 0.006 1.55 (0.67-3.55) 0.304 10 (9) -   -  
Differentiation           
High-Moderate 36 (19) 1.00   1.00   30 (9) 1.00   1.00  
Low 66 (40) 1.14 (0.66-1.97) 0.639 1.95 (0.78-4.91) 0.155 39 (20) 1.83 (0.83-4.03) 0.132 0.97 (0.33-2.88) 0.960
RBM3 expression           
High 82 (38) 1.00   1.00   61 (19) 1.00   1.00  
Low 38 (27) 2.19 (1.33-3.61) 0.002 1.95 (1.17-3.25) 0.010 25 (16) 3.21 (1.64-6.30) 0.001 3.02 (1.45-6.29) 0.003