Overall survival - R0 resection | Recurrence free survival - R0 resection + M0 disease | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | p-value | Adjusted | p-value | Unadjusted | p-value | Adjusted | p-value | |||
n (events) | HR (95% CI) | HR (95% CI) | n (events) | HR (95% CI) | HR (95% CI) | |||||
Age | ||||||||||
Continuous | 120 (65) | 1.04 (1.02-1.07) | <0.001 | 1.06 (1.03-1.09) | <0.001 | 86 (65) | 1.00 (0.97-1.03) | 0.909 | 1.03 (0.99-1.07) | 0.100 |
Gender | ||||||||||
Female | 26 (15) | 1.00 | 0.843 | 1.00 | 0.915 | 16 (3) | 1.00 | 1.00 | ||
Male | 94 (50) | 0.85 (0.48.1.52) | 0.97 (0.51-1.83) | 70 (32) | 2.83 (0.87.9.26) | 0.084 | 3.31 (0.96-11.40)) | 0.058 | ||
T-stage | ||||||||||
T1 | 17 (5) | 1.00 | 1.00 | 10 (1) | 1.00 | 1.00 | ||||
T2 | 31 (17) | 2.12 (0.81-6.00) | 0.119 | 1.35 (0.46-3.99) | 0.582 | 24 (7) | 3.26 (0.40-6.00) | 0.269 | 3.12 (0.30-31.88) | 0.338 |
T3 | 56 (34) | 2.59 (1.01-6.64) | 0.047 | 1.04 (0.36-3.00) | 0.942 | 43 (22) | 6.42 (0.86-47.71) | 0.069 | 3.90 (0.41-36.99) | 0.236 |
T4 | 15 (9) | 3.04 (1.01-9.08) | 0.047 | 1.24 (0.35-4.35) | 0.739 | 8 (5) | 10.06 (1.17-86.42) | 0.035 | 4.38 (0.35-55.05) | 0.253 |
N-stage | ||||||||||
N0 | 45 (18) | 1.00 | 1.00 | 35 (3) | 1.00 | 1.00 | ||||
N1 | 23 (11) | 1.30 (0.61-2.76) | 0.489 | 1.67 (0.79-3.58) | 0.188 | 18 (10) | 8.08 (2.22-29.40) | 0.001 | 12.36 (3.19-47.86) | <0.001 |
N2 | 27 (17) | 1.98 (1.02-3.84) | 0.045 | 2.65 (1.32-5.31) | 0.006 | 22 (13) | 10.53 (2.99-37.06) | <0.001 | 13.07 (3.52-48.53) | <0.001 |
N3 | 25 (19) | 3.36 (1.75-6.47) | <0.001 | 4.85 (2.42-9.70) | <0.001 | 11 (9) | 18.01 (4.81-67.44) | <0.001 | 27.19 (6.64-111.25) | <0.001 |
M-stage | ||||||||||
M0 | 96 (50) | 1.00 | 1.00 | 96 (50) | 1.00 | 1.00 | ||||
M1 | 10 (9) | 2.74 (1.34-5.59) | 0.006 | 1.55 (0.67-3.55) | 0.304 | 10 (9) | - | - | ||
Differentiation | ||||||||||
High-Moderate | 36 (19) | 1.00 | 1.00 | 30 (9) | 1.00 | 1.00 | ||||
Low | 66 (40) | 1.14 (0.66-1.97) | 0.639 | 1.95 (0.78-4.91) | 0.155 | 39 (20) | 1.83 (0.83-4.03) | 0.132 | 0.97 (0.33-2.88) | 0.960 |
RBM3 expression | ||||||||||
High | 82 (38) | 1.00 | 1.00 | 61 (19) | 1.00 | 1.00 | ||||
Low | 38 (27) | 2.19 (1.33-3.61) | 0.002 | 1.95 (1.17-3.25) | 0.010 | 25 (16) | 3.21 (1.64-6.30) | 0.001 | 3.02 (1.45-6.29) | 0.003 |