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Table 2 Hazard ratios of death and recurrence according to clinicopathological factors and RBM3 expression in cases with radically resected primary tumours and radically resected primary tumours/distant metastasis-free disease, respectively

From: High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death

  

Overall survival - R0 resection

Recurrence free survival - R0 resection + M0 disease

  

Unadjusted

p-value

Adjusted

p-value

 

Unadjusted

p-value

Adjusted

p-value

 

n (events)

HR (95% CI)

 

HR (95% CI)

 

n (events)

HR (95% CI)

 

HR (95% CI)

 

Age

          

Continuous

120 (65)

1.04 (1.02-1.07)

<0.001

1.06 (1.03-1.09)

<0.001

86 (65)

1.00 (0.97-1.03)

0.909

1.03 (0.99-1.07)

0.100

Gender

          

Female

26 (15)

1.00

0.843

1.00

0.915

16 (3)

1.00

 

1.00

 

Male

94 (50)

0.85 (0.48.1.52)

 

0.97 (0.51-1.83)

 

70 (32)

2.83 (0.87.9.26)

0.084

3.31 (0.96-11.40))

0.058

T-stage

          

T1

17 (5)

1.00

 

1.00

 

10 (1)

1.00

 

1.00

 

T2

31 (17)

2.12 (0.81-6.00)

0.119

1.35 (0.46-3.99)

0.582

24 (7)

3.26 (0.40-6.00)

0.269

3.12 (0.30-31.88)

0.338

T3

56 (34)

2.59 (1.01-6.64)

0.047

1.04 (0.36-3.00)

0.942

43 (22)

6.42 (0.86-47.71)

0.069

3.90 (0.41-36.99)

0.236

T4

15 (9)

3.04 (1.01-9.08)

0.047

1.24 (0.35-4.35)

0.739

8 (5)

10.06 (1.17-86.42)

0.035

4.38 (0.35-55.05)

0.253

N-stage

          

N0

45 (18)

1.00

 

1.00

 

35 (3)

1.00

 

1.00

 

N1

23 (11)

1.30 (0.61-2.76)

0.489

1.67 (0.79-3.58)

0.188

18 (10)

8.08 (2.22-29.40)

0.001

12.36 (3.19-47.86)

<0.001

N2

27 (17)

1.98 (1.02-3.84)

0.045

2.65 (1.32-5.31)

0.006

22 (13)

10.53 (2.99-37.06)

<0.001

13.07 (3.52-48.53)

<0.001

N3

25 (19)

3.36 (1.75-6.47)

<0.001

4.85 (2.42-9.70)

<0.001

11 (9)

18.01 (4.81-67.44)

<0.001

27.19 (6.64-111.25)

<0.001

M-stage

          

M0

96 (50)

1.00

 

1.00

 

96 (50)

1.00

 

1.00

 

M1

10 (9)

2.74 (1.34-5.59)

0.006

1.55 (0.67-3.55)

0.304

10 (9)

-

 

-

 

Differentiation

          

High-Moderate

36 (19)

1.00

 

1.00

 

30 (9)

1.00

 

1.00

 

Low

66 (40)

1.14 (0.66-1.97)

0.639

1.95 (0.78-4.91)

0.155

39 (20)

1.83 (0.83-4.03)

0.132

0.97 (0.33-2.88)

0.960

RBM3 expression

          

High

82 (38)

1.00

 

1.00

 

61 (19)

1.00

 

1.00

 

Low

38 (27)

2.19 (1.33-3.61)

0.002

1.95 (1.17-3.25)

0.010

25 (16)

3.21 (1.64-6.30)

0.001

3.02 (1.45-6.29)

0.003