Table 1 Expression and relevant regulatory functions of some investigated miRs in MM cells in the context of BMME components

miR-15a/16

Down-regulated

Regulating MM cell proliferation through AKT3, MAPKs and NFκB pathways and by targeting cyclin D1, cyclin D2 and CDC25A

[10]

miR-15a/16

Down-regulated

induction of BMSC-mediated drug resistance in MM cells, possibly through IL-6

[28, 35]

miR-21

Up-regulated

Induction of BMSC-mediated drug resistance in MM cells partially through NFκB pathway and by targeting RhoB

[27]

miR-199a-5p

Down-regulated

Regulating bone marrow angiogenesis through targeting HIF-1α in MM cells and modulating interaction with BMSCs and bone marrow endothelial cells

[32]

miR-135b

Up-regulated

Up-regulated in MM bone marrow mesenchymal stem cells following interaction with MM cells, impairing osteogenesis by targeting SMAD5

[34]

miR-199a, -24-3p, 15a-5p, 16-5p

Down-regulated

Down-regulated in MM mesenchymal cells, contributing to impaired osteogenesis

[33]