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Table 4 Frequency of three monocyte subsets in different diseases

From: Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

Disease CD14 ++CD16 -(Classical, phagocytic) CD14 ++CD16 +(Intermediate, inflammatory) CD14 +CD16 ++(Non-classical, patrolling) Functional change associated with CD14 ++CD16 -MC expansion PMID #
Congestive HF   6.4%↑   CD143 (ACE) ↑, Creatine↑, GFR↓, albumin↓ 20364047
CKD   42 → 70 cells/μl 55 → 130 cells/μl   20943670
RA   5%↑   Th17 cells expansion 22006178
AAA   2.24%↑ 1.9%↑   23348634
Stroke   3%↑ 3%↓   19293821
HIV-2   7%↑   Myeloid dendritic cell depletion 23460749
Sepsis No change 11.5%↑ 6%↑ Phagocytosis↓, CD86↑, HLA-DR↓, IL-1β↓, IL-10↑ 12028567
Sepsis 9.5%↓ 12%↑ 3.4%↓ HLA-DR↓, TNFα & IL-1β ↓,IL-10↑ 19604380
Hepatitis B 6.2%↓ 3.3%↑ 2.5%↑ HLA-DR↑,TNF α ↑, IL-6↑, IL1β ↑, Th17 cells expansion 21390263
HIV 2.5%↓ 3%↑ 3%↑ CD163(scavenger receptor)↑ 21625498
Denque fever 12 ~ 18%↓ 3 ~ 7%↑   HLA-DR ↓, ICAM ↑, serum TNFα↑, IL-18 ↑, IFNγ ↑ , 20113369
Tuberculosis 10%↓ 9%↑ 13%↑ TNFα ↑, apoptosis↑, Il-10↓ 21621464
  1. Circulating classical (CD14++CD16-, also described as CD14+ CD16-, phagocytic), intermediate (CD14++CD16+, also described as CD14+ CD16+, inflammatory) and non-classical (CD14+ CD16++, also described as CD14dimCD16+, patrolling) MC counts were examined in human disease as indicated. The percentage change of monocyte subsets and some functional measurements are recorded. We used PMID # to cite individual manuscripts reporting these studies. ACE, angiotensin converting factor; GFR, glomerular filtration rate; CD86, co-stimulatory molecule, HLA-DR, human leukocyte antigen DR (MHC-II, major histocompatibility complex class II); RA, rheumatoid arthritis; AAA, abdominal aortic aneurysms; HF, heart failure; CKD, chronic kidney disease; GFR, glomerular filtration rate; HIV, human immunodeficiency virus; ↑, increase; ↓, decrease; →, change to.