Table 1 Accuracy of diagnostic panels for NASH

Dixon [48]

HAIR score

105

0.90

score>2

80

89

n/a

n/a

(hypertension, ALT>40 U/L, IR index>5)

Palekar [49]

age≥50 years, female gender, AST≥45 U/L,

80

0.76

score≥3

73.7

65.7

68.2

71.4

BMI≥30 kg/m², AAR ratio≥0.8, HA≥55 mcg/L

Poynard [50]

NashTest

257

0.78

n/a

33

94

66

81

(age, sex, height, weight, triglyceride, GGT,

cholesterol, alpha2macroglobulin, AST, ALT,

apolipoprotein A1, haptoglobin, total bilirubin)

Gholam [51]

AST, presence of diabetes

97

0.82

8.22

76

66

n/a

n/a

Campos [52]

NASH Clinical Scoring System for Morbid

186

0.80

0-2

7

93

obesity (hypertension, type 2 diabetes,

3-4

27

73

AST≥27 U/L, ALT ≥27 U/L, sleep apnea,

5

59

41

non-black race)

6-7

93

7

Ulitsky [53]

diabetes, ALT >40 U/L, triglyceride >150

253

0.76

0-1

10.6

89.4

mg/dL, sleep apnea

2-3

24.7

75.3

4

60

40

5

75

25

Shimada [54]

adiponectin≤4 mcg/mL, HOMA-IR≥3,

85

n/a

all 3 +ive

94

74

94

74

type IV collagen 7S≥5 ng/mL

Tarek [56]

CK18 fragments, sFas

95

0.93

−0.5509

88

89

n/a

n/a

Younossi [57]

NASH Diagnostics

101

0.908

0.2772

94.5

70.2

60

97.1

(cleaved and intact CK18 levels,

serum adiponectin and resistin levels)

Sookoain [58]

BMI, waist circumference, ALT, AST, AP,

101

0.795

n/a

n/a

n/a

n/a

n/a

GGT, HOMA, CRP, sICAM-1

Sumida [59]

NAFIC score

177^†

0.851^†

1

94

48

31

86

[serum ferritin (≥200 ng/mL for female,

2

66

91

90

67

≥300 ng/mL for male), fasting insulin ≥10

442^¥

0.782^¥

1

88

43

66

75

μU/mL, type IV collagen ≥5 ng/mL]

2

60

87

85

64

Younossi [60]

NAFLD Diagnostic Panel

79

0.81

0.221

91.2

47.4

60.8

85.7

(diabetes, gender, BMI, triglycerides,

0.3641

79.4

73.7

73

80

apoptotic and necrotic CK18 fragments)

0.6183

44.1

92.1

83.3

64.8