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Figure 1 | Biomarker Research

Figure 1

From: Clinical development of phosphatidylinositol 3-kinase inhibitors for non-Hodgkin lymphoma

Figure 1

The PI3K/Akt/mTOR pathway and relative inhibitors in NHL. Once RTKs binding to the growth factors, the PI3K signaling pathway is triggered. Activated PI3K could phosphorylate PI (4,5) P2 (PIP2) to produce PI(3,4,5)P3 (PIP3). This process is negatively regulated by PTEN. Akt inhibits the Rheb GTPase activity of TSC1/TSC2 dimer by phosphorylating TSC2. Then activated Rheb stimulates mTOR to phosphorylate the p70S6 and 4E-binding protein (4EBP-1), resulting in dysregulation of protein synthesis and cell survival. On the other hand, mTORC2, another type of mTOR complex, could phosphorylate Akt and promote the complete activation of it.

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