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Table 1 Demographic and clinicopathologic characteristics of the patient population as compared to the RTOG 0525 population not used in the analysis

From: Predictive value of tumor recurrence using urinary vascular endothelial factor levels in patients receiving radiation therapy for Glioblastoma Multiforme (GBM)

  RTOG 0611 patients with VEGF (n = 128) RTOG 0525 patients not used in the analysis (n = 997)
Age   
<50 39 (30.5%) 232 (23.3%)
≥50 89 (69.5%) 765 (76.7%)
  Chi-square p-value = 0.07  
Gender   
Female 72 (56.3%) 570 (57.2%)
Male 56 (43.8%) 427 (42.8%)
  Chi-square p-value = 0.84  
KPS   
60-80 45 (35.2%) 383 (38.4%)
90-100 83 (64.8%) 614 (61.6%)
  Chi –square p-value = 0.47  
Surgery   
Biopsy 3 (2.3%) 47 (4.7%)
Partial resection 44 (34.4%) 459 (46.0%)
Total resection 81 (63.3%) 491 (49.2%)
  Chi-square p-value = 0.01  
Neurologic function   
No symptoms 55 (43.0%) 309 (31.0%)
Minor symptoms 48 (37.5%) 468 (46.9%)
Moderate symptoms 24 (18.8%) 215 (21.6%)
Severe symptoms 1 (0.8%) 5 (0.5%)
  Chi-square p-value = 0.02  
RPA class   
III 30 (23.4%) 175 (17.6%)
IV 74 (57.8%) 602 (60.4%)
V 24 (18.8%) 220 (22.1%)
  Chi-square p-value = 0.24  
MGMT status   
Methylated 31 (25.0%) 269 (27.0%)
Unmethylated 66 (53.2%) 527 (52.9%)
Unknown (indeterminate, invalid)/not done 27 (21.8%) 201 (20.2%)
  Chi-square p-value = 0.86  
Treatment arms   
Not randomized 28 (21.9%) 264 (26.5%)
Arm 1 58 (45.3%) 353 (35.4%)
Arm 2 42 (32.8%) 380 (38.1%)
  Chi-square p-value = 0.09  
  1. Q1 first quartile, Q3 third quartile. RPA recursive partitioning analysis.