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Table 1 Demographic and clinicopathologic characteristics of the patient population as compared to the RTOG 0525 population not used in the analysis

From: Predictive value of tumor recurrence using urinary vascular endothelial factor levels in patients receiving radiation therapy for Glioblastoma Multiforme (GBM)

 

RTOG 0611 patients with VEGF (n = 128)

RTOG 0525 patients not used in the analysis (n = 997)

Age

  

<50

39 (30.5%)

232 (23.3%)

≥50

89 (69.5%)

765 (76.7%)

 

Chi-square p-value = 0.07

 

Gender

  

Female

72 (56.3%)

570 (57.2%)

Male

56 (43.8%)

427 (42.8%)

 

Chi-square p-value = 0.84

 

KPS

  

60-80

45 (35.2%)

383 (38.4%)

90-100

83 (64.8%)

614 (61.6%)

 

Chi –square p-value = 0.47

 

Surgery

  

Biopsy

3 (2.3%)

47 (4.7%)

Partial resection

44 (34.4%)

459 (46.0%)

Total resection

81 (63.3%)

491 (49.2%)

 

Chi-square p-value = 0.01

 

Neurologic function

  

No symptoms

55 (43.0%)

309 (31.0%)

Minor symptoms

48 (37.5%)

468 (46.9%)

Moderate symptoms

24 (18.8%)

215 (21.6%)

Severe symptoms

1 (0.8%)

5 (0.5%)

 

Chi-square p-value = 0.02

 

RPA class

  

III

30 (23.4%)

175 (17.6%)

IV

74 (57.8%)

602 (60.4%)

V

24 (18.8%)

220 (22.1%)

 

Chi-square p-value = 0.24

 

MGMT status

  

Methylated

31 (25.0%)

269 (27.0%)

Unmethylated

66 (53.2%)

527 (52.9%)

Unknown (indeterminate, invalid)/not done

27 (21.8%)

201 (20.2%)

 

Chi-square p-value = 0.86

 

Treatment arms

  

Not randomized

28 (21.9%)

264 (26.5%)

Arm 1

58 (45.3%)

353 (35.4%)

Arm 2

42 (32.8%)

380 (38.1%)

 

Chi-square p-value = 0.09

 
  1. Q1 first quartile, Q3 third quartile. RPA recursive partitioning analysis.