Figure 2

The role of PCSK members in various metabolic processes and disorders. The figure illustrates the role of PCSK1, PCSK3, PCSK5, PCSK6, and PCSK9 in lipid (A), glucose (B), and BA (C) metabolism. Arrows with 2 different types of lines indicate the relationship between factors: solid lines with arrow indicate a “positive influence” and dotted lines with arrow indicate a “negative influence.” For example, PCSK3, 5, and 6 inactivates EL (Figure 2A(2)). In contrast, solid lines with arrow indicate a “positive influence.” For example, PCSK9 inhibition decreases serum APOB level (Figure 2(5)).