Figure 1
From: Beyond malignancy: the role of carbohydrate antigen 125 in heart failure
The Mucin family glycoproteins. (A) There are two classes of mucins generated in the cells: secreted mucins and membrane associated mucins. (B) Diagram of the structure of CA-125. CA-125 is encoded by the MUC16 gene which is located on human chromosome 19. CA-125 contains a tandem repeat domain that has repeating sequences high in serine, threonine and proline and is highly O-glycosylated. The C-terminal domain of CA-125 contains multiple extracellular SEA (s ea urchin sperm protein, e nterokinase, and a grin) modules, a transmembrane (TM) domain, and a cytoplasmic tail. CA-125 is also thought to be putatively cleaved at a site in the SEA modules.