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Table 4 Clinical research of GSIs in the treatment of leukemia

From: The emerging roles of Notch signaling in leukemia and stem cells

Test Preclinical study Phase I
Drug RO4929097 MK-0752
Methods 8 mice (leukemia models) were used in each control or treatment group. Six adult and two pediatric patients with leukemia (seven with T-ALL and one with AML) received MK-0752
Percentages of human CD45+ cells were determined
Results No significance in event-free survival [53] Limited antitumor activity and major gastrointestinal toxicity
Comments [75] [76]