Table 4 Clinical research of GSIs in the treatment of leukemia
From: The emerging roles of Notch signaling in leukemia and stem cells
Test | Preclinical study | Phase I |
|---|---|---|
Drug | RO4929097 | MK-0752 |
Methods | 8 mice (leukemia models) were used in each control or treatment group. | Six adult and two pediatric patients with leukemia (seven with T-ALL and one with AML) received MK-0752 |
Percentages of human CD45+ cells were determined | ||
Results | No significance in event-free survival [53] | Limited antitumor activity and major gastrointestinal toxicity |
Comments | [75] | [76] |