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Table 3 Notch in myeloid leukemia

From: The emerging roles of Notch signaling in leukemia and stem cells

Leukemia types Role Mechanism Comments
Non-APL AML Tumor suppressor B cell lymphoma 2 (BCL2) loss and enhanced p53/p21 expression [45]
APL Oncogene Jagged1 and Dll1 were overexpressed. GSIs could reduce self-renewal and colony formation of Kit + Lin-Sca1+ cell [43]
CMML Tumor suppressor Notch1–3−/− or Ncstn−/− mice developed CMML-like disease [53]
CML Tumor suppressor Inhibition of proliferation [54, 55]