Table 3 Notch in myeloid leukemia
From: The emerging roles of Notch signaling in leukemia and stem cells
Leukemia types | Role | Mechanism | Comments |
|---|---|---|---|
Non-APL AML | Tumor suppressor | B cell lymphoma 2 (BCL2) loss and enhanced p53/p21 expression | [45] |
APL | Oncogene | Jagged1 and Dll1 were overexpressed. GSIs could reduce self-renewal and colony formation of Kit + Lin-Sca1+ cell | [43] |
CMML | Tumor suppressor | Notch1–3−/− or Ncstn−/− mice developed CMML-like disease | [53] |
CML | Tumor suppressor | Inhibition of proliferation |