From: The emerging roles of Notch signaling in leukemia and stem cells
Gene | Role | Tissues | Comments |
---|---|---|---|
cyclin D1, cyclin A , p21, p27, | Cell cycle regulators | Hepatocellular cancer, renal cancer | |
c-myc, NF-κB2 , Akt, mTOR, | Cell proliferation and survival | Keratinocytes, liver, T-ALL, | |
Hes1, Hes6 | Embryonic development | Embryonic neural progenitor cell, human pluripotent stem cells | |
VEGF, VEGFR-2 | Angiopoiesis | Osteosarcoma, endothelial and neural cells. | |
MMP-9, MMP-2 | Invasion and metastasis | Osteosarcoma, pancreatic cancer |