Skip to main content

Table 1 Target genes of the Notch signaling pathways

From: The emerging roles of Notch signaling in leukemia and stem cells

Gene

Role

Tissues

Comments

cyclin D1, cyclin A , p21, p27,

Cell cycle regulators

Hepatocellular cancer, renal cancer

[9, 10]

c-myc, NF-κB2 , Akt, mTOR,

Cell proliferation and survival

Keratinocytes, liver, T-ALL,

[11–16]

Hes1, Hes6

Embryonic development

Embryonic neural progenitor cell, human pluripotent stem cells

[17, 18]

VEGF, VEGFR-2

Angiopoiesis

Osteosarcoma, endothelial and neural cells.

[19, 20]

MMP-9, MMP-2

Invasion and metastasis

Osteosarcoma, pancreatic cancer

[19, 21]