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Table 2 Results of TLR4 Asp299Gly and CD14 (C/T -159) SNPs genotyping in patients and controls

From: Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis

Polymorphism TLR4 Asp299Gly

Controls n = 114

SLE n = 127

p

OR (95% CI)

RA n = 100

p

OR (95% CI)

Genotypes

       

A/A

102 (89.4%)

111 (87.4%)

0.61

0.82 [0.34-1.93]

82 (82%)

0.11

0.54 [0.23-1.25]

A/G

12 (10.5%)

16 (12.5%)

  

18 (18%)

  

Alleles

       

A

0.947

0.937

0.62

0.83 [0.36-1.89]

0.91

0.13

0.56 [0.25-1.27]

G

0.052

0.062

  

0.09

  

CD14 C/T -159

       

Genotype

       

CC

45 (39.4%)

36 (28.3%)

  

32 (32%)

  

CT

57 (50%)

66 (51.9%)

  

55 (55%)

  

TT

12 (10.5%)

25 (19.6%)

0.048*

2.08 [0.94-4.67]

13 (13%)

0.57

1.27 [0.41-3.16]

Allele

       

C

0.644

0.543

  

0.594

  

T

0.355

0.456

0.02†

1.53 [1.04-2.24]

0.405

0.28

1,24 [0.82-1.86]

  1. * p comparing the CD14*T/T genotype prevalence between SLE patients and controls.
  2. † p comparing the CD14*T allele frequencies between SLE patients and controls.
  3. Statistical powers: TLR4 genotypes in SLE = 12.2%; TLR4 genotypes in RA = 47.3%; CD14 genotypes in SLE = 62.6%; CD14 alleles in SLE = 47.9% and CD14 genotypes in RA = 14.2%.
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