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Table 2 Results of TLR4 Asp299Gly and CD14 (C/T -159) SNPs genotyping in patients and controls

From: Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis

Polymorphism TLR4 Asp299Gly Controls n = 114 SLE n = 127 p OR (95% CI) RA n = 100 p OR (95% CI)
Genotypes        
A/A 102 (89.4%) 111 (87.4%) 0.61 0.82 [0.34-1.93] 82 (82%) 0.11 0.54 [0.23-1.25]
A/G 12 (10.5%) 16 (12.5%)    18 (18%)   
Alleles        
A 0.947 0.937 0.62 0.83 [0.36-1.89] 0.91 0.13 0.56 [0.25-1.27]
G 0.052 0.062    0.09   
CD14 C/T -159        
Genotype        
CC 45 (39.4%) 36 (28.3%)    32 (32%)   
CT 57 (50%) 66 (51.9%)    55 (55%)   
TT 12 (10.5%) 25 (19.6%) 0.048* 2.08 [0.94-4.67] 13 (13%) 0.57 1.27 [0.41-3.16]
Allele        
C 0.644 0.543    0.594   
T 0.355 0.456 0.02† 1.53 [1.04-2.24] 0.405 0.28 1,24 [0.82-1.86]
  1. * p comparing the CD14*T/T genotype prevalence between SLE patients and controls.
  2. p comparing the CD14*T allele frequencies between SLE patients and controls.
  3. Statistical powers: TLR4 genotypes in SLE = 12.2%; TLR4 genotypes in RA = 47.3%; CD14 genotypes in SLE = 62.6%; CD14 alleles in SLE = 47.9% and CD14 genotypes in RA = 14.2%.
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